Skip to main content


We're creating a new version of this page. See preview

  • Poster presentation
  • Open Access

Clinical remission off medication in greek adults with juvenile idiopathic arthritis during a 17 year follow-up period

  • 1,
  • 2,
  • 2,
  • 3,
  • 1,
  • 1 and
  • 1
Pediatric Rheumatology201412 (Suppl 1) :P152

  • Published:


  • Juvenile Idiopathic Arthritis
  • Disease Onset
  • Retrospective Cohort Study
  • Clinical Remission
  • Improve Treatment


Clinical remission off medication (CR) in patients with Juvenile Idiopathic Arthritis (JIA) is the optimal aim of treat -to -target strategies. No relevant data have been published for Greek young adults so far.


To assess the achievement of CR and identify CR’s predictors in adults with JIA over a-long-term disease course.


JIA patients ≥ 18 years, and a ≥5 years disease duration were enrolled in this longitudinal retrospective cohort study. Radiographic damage was based on total modified Sharp/van der Heijde score (TmSvdHS), articular and extra-articular damage on JADI and physical ability on HAQ-DI.


98 patients (69 females) with a mean age at disease onset of 7.8 years, an interval from onset to last visit of 17.1 years and a current age of 24.9 years were studied. 37.8% achieved ≥ 1 episode of CR and 21.6% ≥2. The 7 JIA subtypes differed in respect to CR attainment (p=0.008), the worst being patients with polyarthritis RF positive (0%) and the best those with persistent oligoarthritis (87.5%). In 51.4% of them CR lasted for ≥5 years. Gender, age at disease onset, ANA and anti-CCP positivity were not correlated with CR. CR duration was significantly correlated with lower JADI-A (p=0.008), JADI-E (p<0.001), TmSvdHS (p=0.002) and HAQ-DI (p=0.018), while predictors of shorter CR state were polyarticular subtype (p=0.004) and longer duration of disease activity within the first 5 years (p=0.001).


Shrinking of disease activity periods in long-term JIA induced by improved treatments leads to extended CR periods and avoids structural damage and physical disability.

Disclosure of interest

None declared.

Authors’ Affiliations

4th Dept of Internal Medicine, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
1st Dept of Pediatrics, Aristotle University of Thessaloniki, Pediatric Immunology and Rheumatology Referral Center, Hippokration Hospital, Thessaloniki, Greece
Dept of Rheumatology, University of Heraklion, Heraklion, Greece


© Dimopoulou et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.