Volume 12 Supplement 1

Proceedings of the 21st European Pediatric Rheumatology (PReS) Congress

Open Access

Micrornas in autoinflammation and autoimmunity

  • Florence Apparailly1
Pediatric Rheumatology201412(Suppl 1):I14

https://doi.org/10.1186/1546-0096-12-S1-I14

Published: 17 September 2014

Micro(mi)RNAs are small non-coding RNAs that play critical roles in physiological networks by regulating genetic programs. They are conserved from worms to mammals and function as negative regulators of protein-encoding gene expression. Research on the role of miRNAs in pathophysiological conditions is very active since 10 years and several works evidenced that miRNAs play a key role in the regulation of immunological functions and the prevention of autoimmunity. I will discuss the involvement of miRNAs in the regulation of innate and adaptive immune functions and in the development of autoimmune disease. Focusing on the role of few miRNAs, I will emphasize the intertwined relationships between tissue homeostasis and immunity, and on how studying miRNAs in autoimmunity and immune-mediated inflammatory disorders will shed light on pathological processes and help identifying novel drug candidates and biomarkers.

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
U844, INSERM

Copyright

© Apparailly; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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