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  • Invited speaker presentation
  • Open Access

Micrornas in autoinflammation and autoimmunity

  • 1
Pediatric Rheumatology201412 (Suppl 1) :I14

https://doi.org/10.1186/1546-0096-12-S1-I14

  • Published:

Keywords

  • Public Health
  • Gene Expression
  • Critical Role
  • Autoimmune Disease
  • Negative Regulator

Micro(mi)RNAs are small non-coding RNAs that play critical roles in physiological networks by regulating genetic programs. They are conserved from worms to mammals and function as negative regulators of protein-encoding gene expression. Research on the role of miRNAs in pathophysiological conditions is very active since 10 years and several works evidenced that miRNAs play a key role in the regulation of immunological functions and the prevention of autoimmunity. I will discuss the involvement of miRNAs in the regulation of innate and adaptive immune functions and in the development of autoimmune disease. Focusing on the role of few miRNAs, I will emphasize the intertwined relationships between tissue homeostasis and immunity, and on how studying miRNAs in autoimmunity and immune-mediated inflammatory disorders will shed light on pathological processes and help identifying novel drug candidates and biomarkers.

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
U844, INSERM, Montpellier, France

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