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  • Invited speaker presentation
  • Open Access

Monitoring local inflammation in JIA

  • 1
Pediatric Rheumatology201412 (Suppl 1) :I11

https://doi.org/10.1186/1546-0096-12-S1-I11

  • Published:

Keywords

  • Arthritis
  • Serum Concentration
  • Inflammatory Disease
  • Juvenile Idiopathic Arthritis
  • Imaging Method

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease which commonly shows a remitting-relapsing course. Monitoring disease activity and adaptation of immune-suppressive therapy is still a challenge in clinical practice. In previous work our group has shown that members of the S100-protein family are reliable biomarkers for monitoring arthritis in JIA patients on medication and that these proteins may even predict risk of relapses in these patients. In my talk I will present novel data regarding the local release mechanism of these proteins during joint inflammation, use of serum concentrations of these S100-proteins for monitoring JIA as well as novel molecular imaging methods based on local S100-protein expression in preclinical models of inflammation and arthritis.

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
University of Münster, Münster, Germany

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