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Monitoring local inflammation in JIA

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease which commonly shows a remitting-relapsing course. Monitoring disease activity and adaptation of immune-suppressive therapy is still a challenge in clinical practice. In previous work our group has shown that members of the S100-protein family are reliable biomarkers for monitoring arthritis in JIA patients on medication and that these proteins may even predict risk of relapses in these patients. In my talk I will present novel data regarding the local release mechanism of these proteins during joint inflammation, use of serum concentrations of these S100-proteins for monitoring JIA as well as novel molecular imaging methods based on local S100-protein expression in preclinical models of inflammation and arthritis.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Roth, J. Monitoring local inflammation in JIA. Pediatr Rheumatol 12 (Suppl 1), I11 (2014).

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