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Immunophenotype

The evolution of cellular and molecular immunology has made available high-throughput discovery tools which can provide an entirely new, comprehensive and multi-dimensional picture of the immune system. A combination of different approaches, such as deep phenotyping by mass and flow cytometry, multiplex gene expression and functional assays, have been applied to identify immunological and epigenetic signatures leading to the prediction of responsiveness to anti-TNF therapy in autoimmune arthritis. These signatures are originated at the microenvironmental interface between the immune system and the target organ and can then be found in the periphery. We will present novel data demonstrating this concept in the context of human autoimmune arthritis.

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Correspondence to Salvatore Albani.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Albani, S. Immunophenotype. Pediatr Rheumatol 12, I10 (2014). https://doi.org/10.1186/1546-0096-12-S1-I10

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Keywords

  • Public Health
  • Gene Expression
  • Arthritis
  • Immune System
  • Flow Cytometry