Table 3 Adverse effects related to subcutaneous injections of methotrexate
Adverse effect | Prevalence | Onset in relation to injection | Number (%) | Duration | Number (%) | ||
|---|---|---|---|---|---|---|---|
Nausea | 23 (56%) | Before | 13 | (56%) | 0 - 5.9 hours | 9 | (39%) |
During/After (< 1 hour) | 6 | (26%) | 6 - 11.9 hours | 4 | (17%) | ||
After (1–6 hours) | 2 | (9%) | 12 - 23.9 hours | 9 | (39%) | ||
After (> 6 hours) | 5 | (22%) | ≥ 24 hours | 1 | (4%) | ||
Vomiting | 14 (34%) | Before | 6 | (43%) | 0 - 5.9 hours | 12 | (86%) |
During/After (< 1 hour) | 4 | (29%) | 6 - 11.9 hours | 0 | (0%) | ||
After (1–6 hours) | 3 | (21%) | 12 - 23.9 hours | 1 | (7%) | ||
After (> 6 hours) | 3 | (21%) | ≥ 24 hours | 1 | (7%) | ||
Headache | 6 (15%) | < 12 hours | 3 | (50%) | < 12 hours | 5 | (83%) |
12 - 24 hours | 2 | (33%) | 12 - 24 hours | 1 | (17%) | ||
> 24 hours | 1 | (17%) | > 24 hours | 0 | (0%) | ||
Fatigue | 12 (29%) | < 12 hours | 1 | (8%) | |||
12 - 24 hours | 9 | (75%) | |||||
> 24 hours | 2 | (17%) | |||||
Anorexia | 11 (31%) | < 12 hours | 4 | (36%) | |||
12 - 24 hours | 6 | (54%) | |||||
> 24 hours | 1 | (9%) | |||||