Table 1 Laboratory characteristics of children with juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE) and healthy controls
Characteristic | p-value | Juvenile idiopathic arthritis | SLE (n = 19) | Healthy controls (n = 28) | ||
|---|---|---|---|---|---|---|
Systemic (n = 27) | Oligoarticular (n = 34) | Polyarticular (n = 35) | ||||
No. girls/boys | - | 7/20 | 27/7 | 27/8 | 14/5 | 20/8 |
Age, years | - | 9.9* (5.3-12.2) | 2.9* (0.4-8.2) | 6.4 (7.2-12.3) | 14.4* (10.6-15.9) | 6.2 (0.9-11.9) |
HMGB1 (pg/ml) | < 0.001 | 17402.50* (6400.57-80844.98) | 3551.97* (108.89-10713.20) | 4374.04* (273.50-93493.88) | 8523.92* (3639.35-98296.88) | 1149.70 (10.89-1976.47) |
sRAGE (pg/ml) | 0.006 | 1237.53* (46.42-6634.4) | 2269.84 (225.60-5137.92) | 1757.76 (230.40-4730.88) | 924.45* (118.08-10569.20) | 2275.80 (162.37-9206.38) |
ESR (mm/h) | < 0.001 | 86* (34–139) | 17* (5–41) | 40* (5–140) | 57* (10–113) | 7 (2–36) |
CRP (mg/l) | < 0.001 | 145.0* (6.9-264.0) | 2.6 (0.2-25.7) | 23.5* (0.1-156.0) | 3.0 (0.6-25.0) | 2.0 (0.1-6.8) |
Hb (g/l) | < 0.001 | 111* (80–128) | 123 (99–144) | 115* (75–140) | 119 (78–140) | 124 (110–145) |
Hct (%) | < 0.001 | 0.34* (0.23-0.56) | 0.37 (0.29-0.43) | 0.35 (0.24-0.43) | 0.36 (0.22-0.42) | 0.37 (0.32-0.52) |
PLT, ×10^9/l | < 0.001 | 397* (125–563) | 391 (180–651) | 363 (131–1038) | 222 (122–568) | 322 (176–414) |
RBC, ×10^12/l | < 0.001 | 4.17* (3.30-4.96) | 4.51 (3.54-5.31) | 4.26* (3.60-5.88) | 4.13* (2.88-5.09) | 4.63 (4.10-5.17) |
WBC, ×10^9/l | < 0.001 | 9.0* (6.4-29.9) | 8.7* (4.0-17.1) | 8.5* (3.5-27.0) | 4.3 (2.0-19.4) | 7.4 (2.5-9.7) |
γ-globulin (%) | < 0.001 | 17.0* (7.8-39.0) | 14.2 (7.9-21.5) | 21.8* (10.0-32.1) | 22.2* (12.0-38.2) | 13.9 (6.8-19.2) |
α2-globulin (%) | < 0.001 | 15.3* (11.2-26.3) | 9.9* (5.2-16.7) | 13.5* (12.9-19.2) | 10.3* (8.0-17.7) | 7.2 (4.9-14.3) |
ANA (RU/ml) | - | 640 (100–10242) | ||||
anti-dsDNA (RU/ml) | - | 285 (68–2480) | ||||
C3 (mg/l) | - | 0.87 (0.32-1.74) | ||||
C4 (mg/l) | - | 0.13 (0.03-0.32) | ||||