Figure 8
From: Blau Syndrome, the prototypic auto-inflammatory granulomatous disease
Schematic representation of the NOD2 signaling pathway. Upon binding of its natural ligand (MDP), the NOD2 protein unfolds and oligomerizes through the NACT domain. This is followed by recruitment of RIP2 kinase protein through CARD-CARD interactions and activation of downstream transcriptional factors (NF-κB and MAP kinase) and secretion of inflammatory cytokines.