Anti-type II collagen antibodies, anti-CCP, IgA RF and IgM RF are associated with joint damage, assessed eight years after onset of juvenile idiopathic arthritis (JIA)

Table 2 Patterns of autoantibodies collected in 17 of 192 patients from the Nordic juvenile idiopathic arthritis database

Patient No	Age at time of onset	IgM RF Cut-off	IgA RF Cut-off	IgG Anti-CCP Cut-off	IgG Anti-Collagen II Cut-off	Articular damage^¤	JIA category^#	Cumulative number of joints affected during the first eight years of disease
Patient No	Years	> 5 U/ml	> 9 U/ml	> 7 U/ml	> 29 U/ml	Articular damage^¤	JIA category^#
1	4.4	5.7	-	-	-	Missing	Systemic	4
2	12.8	6.0	-	-	-	-	Oligoarticular persistent	2
3	13.5	23.0	-	-	-	-	Undifferentiated^*	1
4	9.4	5.5	-	-	-	-	Oligoarticular persistent	2
5	9.3	-	13.0	-	-	-	Enthesitis-related arthritis	4
6	1.5	-	14.0	-	-	1	Oligoarticular extended	18
7	13.2	64.0	17.0	-	-	1	Polyarticular RF-positive	13
8	13.3	132.0	67.0	≥ 340	-	1	Undifferentiated^**	18
9	10.9	17.0	-	≥ 340	-	1	Oligoarticular extended	24
10	1.1	-	-	9.8	-	-	Systemic	6
11	11.8	-	23.0	15.0	-	-	Enthesitis-related arthritis	2
12	11.0	-	11.0	12.0	94.3	1	Polyarticular RF-negative	19
13	11.7	-	-	-	35.9	1	Polyarticular RF-negative	34
14	4.0	-	-	-	46.6	-	Enthesitis-related arthritis	13
15	4.8	-	-	-	30.4	-	Oligoarticular extended	9
16	4.3	-	-	-	72.9	-	Undifferentiated^***	2
17	8.1	-	-	-	230.8	Missing	Oligoarticular persistent	1

^¤Articular damage at eight-year follow-up according to JADI-A (score 0–72) [19].
^#ILAR Edmonton criteria after eight years of disease [2].
^*Oligoarticular persistent joint pattern and presence of IgM rheumatoid factor on two occasions more than three months apart.
^**Polyarticular pattern from onset and psoriasis in first degree relative.
^***Oligoarticular persistent joint pattern and psoriasis in first degree relative.

ISSN: 1546-0096