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PReS-FINAL-2280: Lupus disease activity in a pediatric Colombian cohort with systemic lupus erytematosus

  • AS Diaz Maldonado1,
  • A Monje Gaitan1,
  • N Gamba1 and
  • F Gonzalez1
Pediatric Rheumatology201311(Suppl 2):P270

https://doi.org/10.1186/1546-0096-11-S2-P270

Published: 5 December 2013

Keywords

Systemic Lupus ErythematosusPediatric PatientPediatric PopulationParametric TestDescriptive Study

Introduction

Systemic Lupus Erythematosus (SLE) is disease which may have severe and variable activity in the pediatric population.

Objectives

compare the index of activity in two times at cohort of pediatric patients with SLE.

Methods

Analytic descriptive study. 89 patients with diagnosis SLE (1986 ACR criteria) from a rheumatology center at a pediatric hospital were evaluated at the time of diagnosis and twelve months after. Medical records were reviewed registering the following variables: score SLEDAI, Antinuclear antibodies (ANAs), Anti-DNA antibodies and complement C3 and C4 levels. Analysis was done through parametric and non parametric tests to compare means and proportions using STATA11. Shapiro-Wilk and Wilcoxon tests (non-normally distributed data) were applied.

Results

Median score SLEDAI at the time of diagnosis was 23 (min 4 max 61); after 12 months it was 4 (min 0 max 31) (p = 0.001). Antinuclear antibodies (ANAs) reactivity at the diagnosis was 88,1%; after 12 months it was 6,67% (p = 0.17). Anti-DNA antibodies reactivity at the diagnosis was 66,7%; after 12 months it was 56,41% (p = 0.01). C3 level was diminished in 67,95% of patients at the diagnosis; after 12 months it was diminished in 33,3% of patients (p = 0.01). C4 level was diminished in 71,7% of patients at the diagnosis; after 12 months it was diminished in 40% of patients (p = 0.01).

Conclusion

Statistical significance was documented regarding score SLEDAI, Anti-DNA antibodies reactivity, hypocomplementemia for the time of diagnosis and twelve month follow-up. This suggests that improvement in disease activity was due to the established treatment.

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
Reumatologia Pediatrica, Hospital de La Misericordia, Bogota, Colombia

Copyright

© Diaz Maldonado et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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