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PReS-FINAL-2206: Clinical experiences in patients with chronic recurrent multifocal osteomyelitis (CRMO)


Chronic recurrent multifocal osteomyelitis (CRMO) is a form of chronic nonbacterial osteitis (CNO) characterized by one or more lytic bone lesions with no identifiable cause. (CRMO) is a rare (prevalence less than 1/1,000,000) auto-inflammatory disorder, characterized by relapsing and remitting episodes of pain related to the presence of foci of sterile bone inflammation.


We describe the clinical and laboratory features and treatment of a cohort of children with CRMO.


We retrospectively reviewed clinical, pathological and radiological data of children with CRMO at single tertiary pediatric center from Turkey. The diagnosis of CRMO was based on evidence of recurrent osteomyelitis with radiographic evidence of chronic osteomyelitis involving at least two sites in the absence of infectious cause in a child less than 14 years old.


Six patients were assessed (34 females and 6 males) with a median age at diagnosis of 9,5 yrs (range 5-16). Median number of initial bony lesions was 2 at onset and 3.5 over disease course. Median time since diagnosis was 1.5 yrs) and median duration of active disease 0.7 yrs. Two patients had active disease at follow-up and continued to have pain. Two patients were treated with steroid, colchicine and sulphasalazine. Two patients had methotrexate, 1 had colchicine while 1 had nonsteroidal anti-inflammatory drug.


This report indicates that CRMO may be overlooked in our community. Early diagnosis and treatment are required to avoid potential complications.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Sozeri, B., Yildiz, B., Sezak, M. et al. PReS-FINAL-2206: Clinical experiences in patients with chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol 11 (Suppl 2), P196 (2013).

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