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PReS-FINAL-2123: Feto-maternal outcome in patients with systemic sclerosis


Progressive systemic sclerosis is a life threating disease typically involve the heart, lungs, and other organs. pregnancy is a stressful condition that can affect the course of the disease.


To study the maternal and fetal outcomes in pregnant women with Systemic Sclerosis (ssc) and to analyze the possible associated risk factors.


Twenty pregnant women with ssc and twenty age-matched low risk pregnant women were recruited in this study. Patients were evaluated clinically and laboratory at the entry of the study and at monthly intervals. Different pregnancy outcome measures were studied. Impacts of pregnancy on scleroderma patients were determined during and after pregnancy. The possible associated risk factors were analyzed.


Twenty ssc pregnant women were recruited in this study with a mean age 29.6 ± 3. Eight (40%) of them had limited ssc, and twelve (60%) had diffuse type. Pregnancies were complicated by maternal flare of underlying disease in six (30%) pregnant patients. Six patients (30%) had preterm labor. Four patients (20%) had small for gestational age (SGA) infants, two of them (10%) had intra uterine growth retardation (IUGR). Two patients (10%), with diffuse type, fulfilled criteria of antiphospholipid syndrome (APS) but unfortunately the pregnancy ended in miscarriage. Eight (40%) full-term infants were born two of them were SGA, 2 cases with miscarriage due to renal crisis and pulmonary hypertension and another two cases with intra uterine fetal death (IUFD). The live birth rate was 14/20 (70%) in ssc group.


Women with ssc can safely have healthy pregnancies if pregnancy is planned when the disease is stable and managed by a multidisciplinary team during pregnancy.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Maher, S., Ismail, F. PReS-FINAL-2123: Feto-maternal outcome in patients with systemic sclerosis. Pediatr Rheumatol 11 (Suppl 2), P135 (2013).

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