- Oral presentation
- Open Access
PReS-FINAL-2193: Assessment of construct validity of new measures of global disease activity, physical function and quality of life in children with juvenile dermatomyositis
© Ferrari et al.; licensee BioMed Central Ltd. 2013
Published: 5 December 2013
Juvenile dermatomyositis (JDM) is a multisystem vasculopathic disease that affects primarily the skin and muscle and is characterized by high risk of morbidity and long-term damage. Regular patient assessment through standardized quantitative clinical measures is important to monitor the disease course over time and to evaluate treatment effectiveness. However, only a few outcome measures specifically validated for use in JDM are available.
To investigate the construct validity of the following new clinical measures for JDM developed by our group: 1) JDM-Act (global disease activity); 2) MyoFun (physical function); 3) Pediatric Rheumatology Quality of Life scale, PRQL (health related quality of life).
Construct validity was assessed by computing the correlations between the new clinical measures and conventional JDM outcome measures by means of the Spearman's correlation coefficient. Correlations were considered good, moderate, or poor when the rs was > 0.7, 0.4-0.7, or < 0.4, respectively.
JDM-Act Global VAS
PRQL total score
The new clinical measures showed good construct validity. By documenting this key measurement property, we have shown that the new tools are valid instruments for the assessment of children with JDM and are, therefore, potentially applicable in both clinical and research contexts. Because the new measures are simpler and shorter than most existing instruments, they may help foster the incorporation of quantitative clinical assessment in standard clinical practice.
Disclosure of interest
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.