Volume 11 Supplement 1

7th Congress of International Society of Systemic Auto-Inflammatory Diseases (ISSAID)

Open Access

P01-005 – Idiopathic uveitis and FMF

  • F Salehzadeh1, 2,
  • O Yasrebi2,
  • S Jahangiri1 and
  • S Hosseiniasl3
Pediatric Rheumatology201311(Suppl 1):A9

https://doi.org/10.1186/1546-0096-11-S1-A9

Published: 8 November 2013

Introduction

Familial Mediterranean fever (FMF) is an auto inflammatory disease characterized by attacks of fever and polyserositis. FMF is often associated with other autoimmune diseases such as rheumatoid arthritis, PAN, Behcet.

Objectives

Uveitis is an inflammatory process of eyes caused by underlying infectious and inflammatory disorders. This study investigates the probable relationship between Idiopathic Uveitis and familial Mediterranean fever.

Methods

Patients with idiopathic uveitis that didn't have Infectious and inflammatory causes referred to the genetic laboratory to12 common MEFV genes analysis. P369S, F479L, M680I(G/C), M680I(G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q mutations were analysed by using amplification refractory system for 11 of those and the PCR was performed for E148Q.

Results

12 patients with idiopathic uveitis were enrolled in this study. 10 of them were female and 2 were male. The youngest patient was a 7-year-old child and the oldest was 57. The most common complaints of patients was blurred vision and then eye redness. One patient was heterozygous for Wt/R761H in the MEFV genetic analyses. Genetic analysis of 12 most common MEFV mutations in the patients with idiopathic uveitis didn't have any positive results.

Conclusion

According to the analysis of 12 most common MEFV gene mutations, FMF is not an underlying cause of idiopathic uveitis. On the other hand uveitis merely could not be the first presentation of FMF.

Disclosure of interest

None declared

Authors’ Affiliations

(1)
Pediatric Rheumatology, Bouali Hospital
(2)
Pediatric Rheumatology
(3)
Genetic, Emam Khomeini hospital

Copyright

© Salehzadeh et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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