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  • Meeting abstract
  • Open Access

P01-039 – Autonomic functions in children with FMF

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Pediatric Rheumatology201311 (Suppl 1) :A43

  • Published:


  • Heart Rate Variability
  • Familial Mediterranean Fever
  • Autonomic Dysfunction
  • Autonomic Function
  • Ventricular Tachyarrhythmia


Familial Mediterranean Fever (FMF) is an autoinflammatory disorder characterized by recurrent fever associated with inflammation of serous membranes. There is no study reporting the assessment of autonomic functions by using heart rate variability (HRV) in children with FMF. HRV is a practical and reliable method for evaluation of autonomic functions. HRV studies have pointed to the presence of autonomic dysfunctions in many autoinflammatory disorders, possible contributing factors to ventricular tachyarrhythmias and sudden cardiac death in these patients.


In this study, we investigated possible alterations in cardiac autonomic functions and other probable cardiac effects in children with FMF by HRV analyses and conventional echocardiography.


In each patient, it was performed twelve lead electrocardiography (ECG) at 25 mm/s (paper speed), 24 h ambulatory electrocardiographic monitorization (AECG), and transthoracic echocardiography by a Siemens Acuson Sequoia C256 cardiac ultrasonographic scanner, with 2.5- to 3.5-MHz transducers.


Seventy FMF patients and 50 healthy controls were enrolled in the study. It was noted that SDNN (standard deviation of all NN intervals) value was lower in patients with FMF as compared to the control group. Frequency-dependent HRV parameters were similar in both groups. There was no difference in patient and control groups in terms of conventional echocardiographic parameters.


Studies with larger cohorts and more comprehensive methods are required to assess the presence and consequences of possible autonomic dysfunction in children with FMF.

Disclosure of interest

None declared.

Authors’ Affiliations

Pediatric Cardiology, Hacettepe University, School of Medicine, Ankara, Turkey
FMF Arthritis Vasculitis and Orphan Disease Research Center, Hacettepe University, School of Medicine, Ankara, Turkey
Pediatric Rheumatology, Gulhane Military Medical Faculty, Hacettepe University, School of Medicine, Ankara, Turkey
Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey


© Fidanci et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.