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P01-034 – Cancer in FMF: a population based study Israel


Recurrent or persistent inflammation, featuring Familial Mediterranean Fever (FMF), may induce, promote, or influence susceptibility to carcinogenesis. However, the association between FMF and malignancy was rarely described before.


To assess the prevalence of malignancy in FMF.


Demographic data of FMF patients, followed in the national FMF center at Sheba medical center (n=8352) and Hadassah Medical Center (n=1083) were obtained from FMF patient hospital registries. The prevalence of cancer in the general population, and in the study registries was attained from the cancer registry of Israel and analyzed according to age, origin, and cancer type. The Standardized incidence rates (SIR) of the different cancers in FMF patients were calculated and compared to the cancer SIR of the parallel Israeli ethnic population.


Of 9435 FMF patients (4696 men, 4739 female), 363 developed cancer during the years 1970- 2011. FMF female patients developed significantly more lymphoma (Hodgkin and non-Hodgkin) and in-situ cervical cancer than the matched general population, SIR 2.07 (95% CI 1.12-2.99) and 1.86 (95% CI 1.20-2.51), respectively. In contrast, male and female with FMF had a lower gastrointestinal cancer incidence, SIR 0.68 (95% CI 0.42-0.95) and 0.63 (95% CI 0.36-0.90).


The risk for lymphoma and in-situ cervical cancer is increased about twice in FMF. Understanding the underlying mechanism (inflammation? Colchicine? Genetic predisposition?) may improve patient prognosis.

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Correspondence to B Zvi.

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Brenner, R., Kivity, S., Shinar, Y. et al. P01-034 – Cancer in FMF: a population based study Israel. Pediatr Rheumatol 11, A38 (2013).

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  • Lymphoma
  • Cervical Cancer
  • Colchicine
  • Cancer Registry
  • Familial Mediterranean Fever