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Pediatric Rheumatology

Open Access

P01-027 – Normal HRV in colchicine-resistant FMF patients

  • U Nussinovitch1 and
  • A Livneh2
Pediatric Rheumatology201311(Suppl 1):A31

Published: 8 November 2013


Heart Rate VariabilityColchicineAmyloidosisFamilial Mediterranean FeverFamilial Mediterranean Fever Patient


The relationship between autonomic nervous system (ANS) dysfunction and Familial Mediterranean Fever (FMF) is controversial. Heart rate variability (HRV) is a powerful, simple and reliable technique for the evaluation of ANS dysfunction. Recently, we reported on normal HRV parameters, suggestive of normal ANS function, in patients with uncomplicated FMF. Also, we reported on an association between decreased HRV parameters (suggestive of ANS dysfunction), and amyloidosis of FMF, particularly at a progressive stage.


The aim of the current study was to evaluate whether FMF patients, who do not respond to colchicine treatment, and thereby endure persistent inflammation, have abnormal ANS function, using the HRV tool.


Twenty-four FMF patients suffering from recurrent FMF attacks despite treatment with a maximal colchicine dose, were selected for the study. Electrocardiogram was measured under strict conditions and HRV parameters were calculated. Results were compared with age- and sex- matched unaffected controls.


No statistically significant difference was found between the groups in any determined HRV parameter: maximal RR, minimal RR and average RR intervals, standard deviation of RR interval, square root of the mean squared differences of successive RR intervals, HRV triangular index, NN50, pNN50, and power spectral analysis. Nevertheless, a statistically non-significant trend towards lower HRV parameters was observed in the colchicine non-responders group.


Although a small difference in HRV parameters cannot be entirely excluded in the current study design, FMF patients, in whom colchicine did not provide adequate symptomatic relief and who did not develop amyloidosis, seem to have HRV parameters similar to those of healthy subjects, suggestive of normal ANS function.

Disclosure of interest

None declared.

Authors’ Affiliations

Israel Naval Medical Institute, Haifa, Israel
The Heller Institute of Medical Research, and Department of Medicine F, Sheba Medical Center, Tel Hashomer, Israel


© Nussinovitch and Livneh; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.