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OR6-006 – IL36RN alleles in skin auto-inflammation
Pediatric Rheumatology volume 11, Article number: A101 (2013)
Our group identified recessive mutations of the IL36RN gene in patients affected by Generalised Pustular Psoriasis (GPP), a severe skin disorder characterised by acute episodes of pustulation, fever and systemic upset.
Here, we sought to characterise the phenotypic spectrum associated with IL36RN alleles. We specifically investigated the possibility that IL36RN defects may also contribute to chronic forms of pustular psoriasis and to common plaque psoriasis (also known as psoriasis vulgaris or PV).
We screened a total of 598 patients affected by GPP (n=84), or by localised forms of pustular psoriasis (9 cases of Acrodermatitis Continua of Hallopeau and 139 cases of Palmoplantar Pustulosis) and PV (n=366).
We found IL36RN recessive mutations in patients with GPP (7/84) and localised pustular psoriasis (2/9 cases of Acrodermatitis Continua of Hallopeau and 3/139 cases of plamar-plantar pustulosis), but not among PV cases. Of note, we also identified several affected individuals who carried a single heterozygous mutation. In fact, we uncovered a significant enrichment of heterozygous IL36RN alleles among patients with pustular psoriasis (frequency in cases 1.4% vs. 0.3% in controls, P=0.004), but not among subjects with PV (0.4% cases vs. 0.3% controls, P=0.77).
We have demonstrated a significant overlap in the genetic basis of acute generalised and chronic localised forms of pustular psoriasis. The recurrence of similar mutations in both disease groups and the observation of affected individual carrying a single recessive allele suggest that other genes may modify the phenotypic expression of IL36RN variants.
Our findings argue against the notion that IL36RN alleles may contribute to PV. In the light of recent data suggesting a pathogenic role of IL-36 in a mouse model of the disease, our results emphasize the importance of genetic studies in the molecular dissection human auto-inflammatory diseases.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Capon, F., Setta-Kaffetzi, N., Berki, D. et al. OR6-006 – IL36RN alleles in skin auto-inflammation. Pediatr Rheumatol 11 (Suppl 1), A101 (2013). https://doi.org/10.1186/1546-0096-11-S1-A101
- Affected Individual
- Localise Form
- Plaque Psoriasis
- Recessive Mutation