Pediatric Rheumatology

Table 2 Allele and genotype distribution of five polymorphisms in the promoter of DC-SIGN among IVIG responders and non-responders in three ethnic groups

From: DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease

	Minor allele frequency			Global test		Additive model
	HapMap*	IVIG responders	IVIG non-responder	Allelic	Genotype	Odds ratio	p-value
				p-value	p-value	(OR)
All ethnic group		(n = 277)	(n = 94 )
rs2287886		0.40	0.43	0.51	0.48	1.11	0.53
rs4804803		0.15	0.16	0.73	0.94	1.00	0.73
rs735240		0.42	0.38	0.36	0.09	0.92	0.37
rs11465360		0.06	0.06	0.98	0.98	0.91	0.96
rs4804804		0.35	0.37	0.56	0.61	0.90	0.58
Whites		(n = 158)	(n = 62)
rs2287886	0.31	0.35	0.36	0.92	0.42	1.18	0.92
rs4804803	0.26	0.17	0.21	0.30	0.57	1.53	0.29
rs735240	0.45	0.46	0.41	0.31	0.23	0.65	0.31
rs11465360	0.05	0.07	0.07	0.96	0.96	0.92	0.96
rs4804804	0.31	0.35	0.35	0.96	0.57	0.88	0.96
Asians		(n = 64)	(n = 12)
rs2287886	0.71	0.57	0.79	0.04	0.08	1.76	0.05
rs4804803	0.04	0.11	0.05	0.28	0.57	0.68	0.29
rs735240	0.26	0.24	0.19	0.32	0.56	0.71	0.31
rs11465360		0.03	0.04	0.72	0.71	1.14	0.71
rs4804804	0.41	0.37	0.50	0.23	0.13	1.37	0.23
Hispanics		(n = 55)	(n = 20)
rs2287886	0.36	0.33	0.42	0.34	0.19	2.21	0.34
rs4804803		0.14	0.08	0.33	0.61	0.37	0.33
rs735240	0.44	0.48	0.43	0.54	0.22	0.53	0.53
rs11465360		0.05	0.03	0.56	0.55	0.81	0.55
rs4804804	0.21	0.31	0.35	0.32	0.66	0.51	0.69

*For Hispanics, the frequency from the Hapmap Mexican population is shown; OR based on the additive model for minor allele.

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