Long-term education and employment outcomes in pediatric-onset systemic lupus erythematosus
© Lawson et al; licensee BioMed Central Ltd. 2012
Published: 13 July 2012
Little is known about the long-term functional outcome of adults with pediatric-onset systemic lupus erythematosus (pSLE). We aim to describe education and employment outcomes in this population, and to compare subjects with pSLE to subjects with adult-onset SLE (aSLE) utilizing the UCSF Lupus Outcomes Study (LOS).
Data derive from the 2007 cycle of the LOS, an annual longitudinal telephone survey of diverse English-speaking subjects with confirmed SLE. Only subjects of working age (22-50 years) were included in the analysis (N=326). Subjects were classified as juvenile-onset if age at diagnosis was < 18 years (N=70). Outcome variables included completion of a bachelor’s degree and current employment status. We used logistic regression to compare pSLE and aSLE with and without adjustment for other characteristics that could affect educational attainment and employment outcomes. Age, gender, ethnicity and the presence of renal disease were included as predictors of educational attainment. Predictors of employment included age, gender, ethnicity, renal disease, completion of a bachelor’s degree, self-reported disease activity according to the Systemic Lupus Activity Questionnaire (SLAQ) score, and physical disability according to the SF-36 Scale of Physical Function (SF36-PF).
Regression-adjusted ORs for having completed a bachelor's degree and being employed among subjects age 22-50 with SLE*
OR for having a bachelor's degree (95% CI)†
OR for being employed (95% CI)
Bachelor's degree completed
While subjects with pSLE are just as likely as those with aSLE to complete college education, onset of lupus in childhood significantly increases the risk of not working in adulthood, even when controlling for disease activity. Exploring reasons for low rates of employment and providing vocational support may be important to maximize long-term functional outcomes in patients with pSLE.
Erica F. Lawson: None; Aimee O. Hersh: None; Laura Trupin: None; Emily Von Scheven: None; Edward H. Yelin: None.
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