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Table 5 Treatment received during the course of the disease

From: Is juvenile dermatomyositis a different disease in children up to three years of age at onset than in children above three years at onset? A retrospective review of 23 years of a single center’s experience

Treatment received

3 Years of age and below at onset n = 19

Above 3 years of age at onset n = 59

Total patients

p-value

Plaquenil

1 (5%)

17 (29%)

78

0.035

Immunosuppressant

3 (16%)

16 (27%)

78

0.323

  IVIG

3 (16%)

17 (29%)

78

0.27

  Rituximab

0 (none)

3 (5%)

78

-

• Duration in months of methotrexate therapy

n=13

n = 48

78

-

 

Mean = 24.31

Mean = 35.17

  
 

St Dev = 15.22

St Dev = 27.20

  
 

Median = 23.00

Median = 26.00

  
 

Range = 1 to 51

Range = 4 to 124

  
 

Mode = 12

Mode = 17, 25

  

• Duration in months of oral prednisolone/prednisone therapy

n = 18

n = 55

78

-

 

Mean = 16.89

Mean = 33.33

  
 

St Dev = 13.62

St Dev = 27.62

  
 

Median = 19

Median = 23

  
 

Range = 1 to 50

Range = 4.5-151

  
 

Mode = 19

Mode = 14, 15, 21, 36

  

Non-methotrexate immunosuppressant: anti-tumor necrosis factor biologics, mycophenolate mofetil, cyclosporine and cyclophosphamide

  1. In the younger group: 12/19 patients were started on MTX at the diagnosis but eventually 13/19 received methotrexate during their disease course. While in patients with older onset group: 40/59 patients were started on MTX at diagnosis but eventually 48/59 patients received methotrexate during their disease course.