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Table 2 Laboratory values meeting HLH diagnostic criteria found prior to, during and after trial of anakinra

From: Presentation of hemophagocytic lymphohistiocytosis due to a novel MUNC 13–4 mutation masked by partial therapeutic immunosuppression

HLH diagnostic criteria Patient laboratory values
Timing relative to anakinra trial Admission to prior to anakinra During anakinra One week after anakinra
Cytopenia in ≥ 2 cell lines  
  Anemia No Yes No
  Thrombocytopenia Yes Yes Yes
  Neutropenia Yes Yes Yes
Fasting Hypertriglyceridemia - Yes Yes
Hypofibrinogenemia Yes No -
Hyperferritinemia Yes Yes Yes
Elevated sCD25 - Yes -
NK cell activity   
  LU20 NK reduced markedly reduced -
  CD107a - Yes -
Hemophagocytosis in bone marrow some - numerous
  1. -: laboratory value not measured; NK: natural killer.