Fig. 4

Differences between mean NPX values with 95% confidence intervals of serum and salivary biomarkers in individuals with active (n = 21) compared to inactive JIA (n = 21). NPX = normalized protein expression. MD = mean difference. Biomarkers were selected if the difference between NPX values was significantly different (p < 0.05) or had a difference of at least 0.4 NPX when comparing children with active and inactive JIA. Positive differences indicate higher and negative differences indicate lower biomarker levels in active compared to inactive JIA. The selected serum biomarkers (n = 12, red bars) and salivary biomarkers (n = 41, blue bars) were sorted in descending order. Panels A and B show the difference in serum (A) and saliva (B) for the total group av children with active (n = 21) compared to inactive JIA (n = 21), while Panels C (serum) and D (saliva) show the same differences in n = 28 children with JIA after exclusion of 14 children treated with TNF inhibitors