Fig. 1

Visual illustration of the differences between mean NPX values of serum and salivary biomarkers in children with JIA (N = 42) compared to controls (N = 30). MD = mean difference, NPX = normalized protein expression value, an arbitrary unit on a Log2 scale according to the Proseek multiplex-enhanced extension assay provided by Olink Proteomics. The serum biomarkers in Panel A (red bars) are sorted in descending order and the salivary biomarkers in Panel B (blue bars) are sorted according to the serum biomarkers. Positive differences indicate higher and negative differences indicate lower biomarker levels in JIA compared to controls. The total number of serum samples in JIA was 42 and in controls 29 (1 missing), and saliva samples in JIA were 38 (4 missing), and 30 in controls. The biomarkers with NPX values below the level of detection in more than 60% of the samples have been excluded (5 biomarkers in serum and 19 in saliva)