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Table 1 MR results of causal relationships between immune cells and JIA

From: Gene association analysis to determine the causal relationship between immune cells and juvenile idiopathic arthritis

Outcome

Exposure

No. SNP

PIVW

PFDR

OR

95% CI

Horizontal pleiotropy

Heterogeneity

Egger intercept

SE

P-value

Cochran’s Q

P-value

JIA

CD3 on CM CD8br

18

3.33e-05

0.024**

0.731

0.63–0.848

0.028

0.035

0.437

13.447

0.706

HLA DR on CD14+ CD16- monocyte

22

0.000683

0.168*

0.748

0.633–0.885

0.012

0.052

0.821

40.645

0.006

HLA DR on CD14+ monocyte

21

0.00069

0.168*

0.743

0.627–0.883

0.011

0.053

0.826

38.655

0.007

  1. FDR, FDR, false negative discovery rate, Benjamini-Hochberg method was used for adjustment
  2. SNP Single Nucleotide Polymorphism: OR odds ratio: CI confidence interval
  3. *Indicates significant difference in PFDR at 0.2 level
  4. **indicates significant difference in PFDR at 0.05 level
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Pediatric Rheumatology

ISSN: 1546-0096