Outcomes | No of studies | Certainty assessment | No of patients | Certainty |
|---|
Study design | Risk of bias | Inconsistency | Indirectness | Other considerations | IG | CG |
|---|
CHAQ | 4 | RCT | Not serious | Serious (-1) | Serious (-1) | NO | 124 | 117 | ⊕⊕⊖⊖ | Low |
QoL | 3 | RCT | Serious (-1) | Serious (-1) | Serious (-1) | NO | 81 | 79 | ⊕⊖⊖⊖ | Very Low |
EPM | 2 | RCT | Serious (-1) | Serious (-1) | Serious (-1) | NO | 62 | 61 | ⊕⊖⊖⊖ | Very Low |
VO2peak | 3 | RCT | Serious (-1) | Serious (-1) | Serious (-1) | NO | 81 | 79 | ⊕⊖⊖⊖ | Very Low |
6MWT | 2 | RCT | Not serious | Serious (-1) | Serious (-1) | NO | 70 | 65 | ⊕⊕⊖⊖ | Low |
HRrate | 2 | RCT | Not serious | Very serious (-2) | Serious (-1) | NO | 39 | 33 | ⊕⊖⊖⊖ | Very Low |
Pain | 3 | RCT | Not serious | Serious (-1) | Not serious | NO | 89 | 83 | ⊕⊕⊕⊖ | Moderate |
- Note 6MWT, six-minute walk test. AE, aerobic exercise. CG, control group. CG, control group. CHAQ, Childhood Health Assessment Questionnaire. EPM, Pediatric Escola Paulista de Medicina Range of Motion scale. HRmax, max heart rate. IG, intervention group. IG, intervention group. QoL, Quality of Life. RCT, randomized controlled trial. RCT, randomized controlled trial. RE, resistance exercise. VO2peak, peak oxygen consumption. GRADE Working Group grades of evidence: High quality: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate quality: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low quality: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low quality: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect
