Table 1 Clinical characteristics of two patients

Date of admission

2018/12/29

2018/8/2

Age

3Y11M

7Y10M

Gender

M

M

Blood routine

WBC counts (10⁹/L)

9.68

23.34

4–12.0

PMNs (%)

64.5

86.2

50–75

Hgb (g/L)

101

93

110–155

PLT (10⁹/L)

151

463

100–400

CRP (mg/L)

179.79

183.57

0–8

ESR (mm/h)

48

> 140

0–20

Alb(g/L)

39.1

31.1

32–52

ALT(U/L)

9

8

< 50

AST(U/L)

29

12

15–60

Serum ferritin(µg/L)

218.8

126.2

24–336

triglyceride(mmol/L)

2.15

0.67

< 1.7

LDH(U/L)

352

253

110–295

BUN(mmol/L)

2.86

2.69

1.79–6.43

Creatinine(µmol/L)

45

53

15–77

ASO

1.7

39

0-156

RF (U/ml)

3.1

2.7

0–30

Fibrinogen(g/L)

3.43

5.72

1.8-4

D-dimer(mg/L)

1.24

0.35

< 0.55

IL-2 (pg/ml)

1

1.5

1.1–9.8

IL-4(pg/ml)

1.6

2.3

0.1-3

IL-6 (pg/ml)

60.7

157.8

1.7–16.6

IL-10(pg/ml)

7.6

6.1

2.6–4.9

TNF-α(pg/ml)

1

64.9

0.1–5.2

IFN-γ(pg/ml)

35.3

1.2

1.6–17.3

IgG (g/L)

9.2

17.9

5-10.6

IgG1(g/L)

8.43

/

4.9–11.4

IgG2(g/L)

0.87

/

1.5–6.4

IgG3n (g/L)

0.17

/

0.2–1.1

IgG4n (g/L)

0.16

/

0.08–1.4

IgA (g/L)

4.81

2.45

0.34–1.38

IgM (g/L)

0.54

1

0.44–1.44

IgE (IU/mL)

103

344

< 100

C3 (g/L)

1.75

1.75

0.5–1.5

C4 (g/L)

0.48

0.38

0.1–0.4

CD 19(%)

25.5

19.6

18.5–28

CD3 (%)

68.5

70.7

56–68

CD4 (%)

41.8

44.2

29–40

CD8 (%)

20.4

22.9

19–25

CD3-CD16 + CD56+ (%)

5.9

0.4

9.0–19

CD4/CD8

2.05

1.93

1.1-2

ANA

negative

negative

< 1:80

ANCA

negative

negative

EBVEA-IgM

0.01

0.06

< 1.1

EBVCA-IgM

1.63

1.39

< 40

MP-IgM

0.43

0.02

< 1.1

CP-IgM

0.01

0.06

< 1.1

TSPOT

negative

negative

CMV IgM

/

/