Fig. 1

Histology (P.A.S. stain, magnification 40x): renal biopsy showed 14 glomeruli. In < 50%, variable mesangial hypercellularity was present: focal/segmental in A, mild in B and moderate in C. In A, a focus of endocapillary proliferation was observed (circle). Immunofluorescence (magnification 40x) showed global positivity for IgG+++ (D), IgA++, C3++, C1q+++ (E), kappa light chain+++ and lambda light chain+++. IgM were negative. Electron microscopy (F, magnification 2500x) highlighted many subendothelial deposits (arrows) and laminated zebra bodies in the cytoplasm of few podocytes (rectangle)