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Table 3 Disease activity at first and last study visit in children with PRD

From: Prospective study to characterize adalimumab exposure in pediatric patients with rheumatic diseases

 

Study group A-M (GA-M)

Study group A (GA)

 

First study visit

Last study visit

First study visit

Last study visit

Disease activity parameters, median [IQR]

 CRP, mg/L (ref < 10)

Missing, n (%)

0.1 [0.1, 0.3]

0.300 [0.1, 2.1]

0.6 [0.3, 1.3]

1 (7.1)

0.5 [0.3 1.0]

1 (7.1)

 ESR, mm/h (ref < 15)

Missing, n (%)

6.0 [5.0, 7.0]

1 (7.1)

5.0 [5.0, 7.0]

1 (7.1)

4.0 [4.0, 6.0]

3 (21.4)

7.0 [5.0, 8.0]

3 (21.4)

 PGA, cm

0.5 [0, 1.8]

1.0 [0, 1.8]

0 [0, 1.0]

0 [0, 0]

 PPGA, cm

1.0 [0, 1.8]

0.5 [0, 2.0]

0 [0, 0]

0 [0, 0]

Disease activity in children with JIA (based on the JADAS-10), n (%)

 

n = 12

n = 8

 Inactive

4 (33.3)

4 (33.3)

6 (75.0)

7 (87.5)

 Minimal

4 (33.3)

5 (41.7)

1 (12.5)

0

 Moderate

2 (16.7)

3 (25.0)

1 (12.5)

1 (12.5)

 High

1 (8.3)

0

0

0

 Missing

1 (8.3)

0

0

0

Disease activity in children with uveitis (based on cells in field by SUN), n (%)

 

n = 8 (n = 2 idiopathic uveitis, n = 6 JIA-uveitis)

n = 8 (n = 5 idiopathic uveitis, n = 3 JIA-uveitis)

 Absent

8 (100)

5 (62.5)

5 (62.5)

7 (87.5)

 Minimal

0

2 (25.0)

2 (25.0)

0

 Mild

0

0

1 (12.5)

1 (12.5)

 Missing

0

1 (12.5)

0

0

  1. Abbreviation CRP c-reactive protein, cm centimetre, ESR erythrocyte sedimentation rate, JIA Juvenile idiopathic arthritis, JADAS Juvenile Arthritis Disease Activity Score, IQR Inter-quartile ranges, L litre, mg milligram, PGA physician global assessment, PPGA patient’s /parents global assessment, ref. reference values, SUN standardization of the uveitis nomenclature, GA-M study group adalimumab and methotrexate, GA study group adalimumab