Radiographic damage in hands and wrists of patients with juvenile idiopathic arthritis after 29 years of disease duration

Table 5 Predictors of the aSvdH score and mean CHR at 29-year follow-up

	aSvdH				Mean CHR
	Univariate analyses		Multivariate analyses		Univariate analyses		Multivariate analyses
Variables assessed within 15 years:	B (95% CI)	P value	B (95% CI)	P value	B (95% CI)	P value	B (95% CI)	P value
Oligoarticular onset^a	−48.1 (−85.3 to −10.9)	0.012			0.047 (0.005 to 0.090)	0.028
Polyarticular course^b	NA	NA			−0.060 (−0.120 to 0.000)	0.048
HLA-DRB1*04 positive	67.2 (28.8 to 105.5)	0.001			NA	NA
HLA-B27 positive	NA	NA			0.057 (0.011 to 0.102)	0.016	0.047 (0.013 to 0.082)	0.009
No. joints with LROM at 15 years^c	5.9 (4.7 to 7.2)	<0.001	4.8 (3.4 to 6.3)	<0.001	−0.005 (−0.007 to−0.004)	<0.001	−0.004 (−0.006 to−0.002)	<0.001
ESR at 15 years, mm/h	2.6 (1.7 to 3.5)	<0.001	1.1 (0.3 to 1.9)	0.010	−0.002 (−0.003 to−0.001)	<0.001
CRP at 15 years, mg/l	2.3 (1.2 to 3.3)	<0.001			NA	NA
HAQ at 15 years	53.5 (22.2 to 84.7)	0.001			−0.065 (−0.100 to −0.031)	<0.001	−0.042 (−0.071 to −0.012)	0.007
Total time with active disease at 15-year follow-up, years	5.1 (1.0 to 9.1)	0.015			−0.007 (−0.011 to −0.002)	0.005

^aOligoarticular onset: ≤ 4 active joints first 6 months, from all JIA categories except polyarticular JIA. ^bPolyarticular course: having in total ≥ 5 active joints after 6 months of disease, from all JIA categories except persistent oligoarticular JIA. ^cNumber of joints with LROM at 15 years correlated highly (r >0.7) with physician’s global assessment and number of active joints at 15 years so only joints with LROM was chosen in the model. aSvdH adapted Sharp van der Heijde, CHR carpal height ratio, LROM limited range of motion, NA not applicable

ISSN: 1546-0096