Table 4 Adverse events that led to treatment discontinuation in 99 patients

Recurrent or new-onset uveitis

38

Neuropsychiatric disorders

21

 Behavioral disorders

7

 Headache

6

 Mood disorders/difficulty concentrating

4

 Tics/unintentional movements

2

 Papilledema

1

 Hypoglossal nerve paralysis

1

Gastrointestinal disorders

15

 Inflammatory bowel diseases

10

 Persistent hypertransaminasemia

1

 Abdominal pain

1

 Peritonitis anti-DNA positive

1

 Acute pancreatitis

1

 Nausea or vomiting

1

Infection

13

 Recurrent herpes labialis

2

 Recurrent upper airway infections

2

 Fatal streptococcal sepsis

1

 Tuberculosis

1

 Varicella complicated by porpora fulminans and fasciitis

1

 Osteomyielitis

1

 Cellulitis

1

 Herpetic neuritis

1

 Herpes zoster

1

 CMV hepatitis

1

 Recurrent bronchitis

1

Mucocutaneous disorders

10

 Urticaria

4

 Urticaria angioedema

2

 Cutaneous vasculitis

2

 Itch

1

 Anal Condylomatosis

1

Haematological disorders

5

 Leukopenia

3

 Autoimmune thrombocytopenia

1

 Hypocomplementemia

1

Injection site reactions

4

Pain at injection site

3

Malignancy

2

 Thyroid carcinoma

1

 Bladder carcinoma

1

Others

6

 Persistent cervical lymphadenopathy

2

 Autoimmune thyroiditis

1

 Menometrorrhagia

1

 Abortion

1

 Renal lithiasis

1