Table 2 Data on pamidronate treatment, MRI response, MRI confirmed CRMO relapse, and follow-up

   One day monthly (n)

6/9

   Three day cycle every 3 months (n)

3/9

Cumulative dose of pamidronate in mg/kg/year*

5.0 (4.5–9.5)

Time to > 90% MRI signal resolution after initial treatment (m)*

6.0 (2–12)

Number of IVP cycles required for > 90% MRI signal resolution*

5 (2–10)

Number of patients with clinical resolution of adjacent soft tissue swelling

5/5

Side effects from IVP

   Myalgia and fever with first dose (n)

4/9

   Osteonecrosis of the jaw (n)

0/9

Duration of follow-up after first IVP (m)*

31.4 (24–54)

Number of patients who relapsed

4/9

Time from first IVP to relapse (m)*

12.3 (12–18)

Time to >90% MRI signal resolution after repeat IVP treatment for CRMO relapse (m)

2 (for all patients)

Extra-osseus manifestations during follow-up

   Psoriasis/palmoplantar pustulosis/acne

0/9; 0/9; 1/9

   Synovitis/inflammatory bowel disease

0/9; 0/9