Volume 6 Supplement 1

15thPaediatric Rheumatology European Society (PreS) Congress

Open Access

Autoimmune response following influenza vaccination

  • N Toplak1,
  • T Kveder2,
  • A Trampus-Bakija3 and
  • T Avcin1
Pediatric Rheumatology20086(Suppl 1):P146

DOI: 10.1186/1546-0096-6-S1-P146

Published: 15 September 2008

The aim of this study was to assess autoimmune response following annual influenza vaccination in apparently healthy adults, staff at a children's hospital.

92 healthy adult subjects were tested for autoantibodies including antinuclear antibodies (ANA), anti-extractable nuclear antigen antibodies (anti-ENA), antiphospholipid antibodies (aPL), namely anticardiolipin antibodies (aCL), anti-beta2-glycoprotein I antibodies (aβ2-GPI) and lupus anticoagulant (LA). Blood samples were taken from each participant before annual influenza vaccination, one month and six months after vaccination.

Before influenza vaccination 26% of participants were positive for ANA, 1% for anti-ENA, 16% for aCL, 7% for aβ2-GPI and 2% for LA. One month after influenza vaccination 76% of participants showed no change in autoantibodies titres. Six months after influenza vaccination 74% of participants showed no change in autoantibodies titres. Overall, there was no statistically significant difference in the percentage of positive ANA, aCL, aβ2-GPI and LA before and 6 months after the vaccination. Five participants developed autoantibodies 6 months after the vaccination and one who was initially low positive for ANA became highly positive (1:320). Eleven participants had only transiently increased autoantibodies. Persistently positive or progressively increased levels of autoantibodies during 6 months' follow up were observed in 6 persons (7%).

Our study showed a high percentage of positive autoantibody testing among healthy adult staff at a children's hospital. There was no statistically significant difference in the percentage of positive autoantibodies before and after influenza vaccination. However, our study clearly demonstrated induction of autoantibodies production in selected subjects.

Authors’ Affiliations

(1)
Department of Allergology, Rheumatology and Clinical immunology, University Children's Hospital, University Medical Centre
(2)
Department of Rheumatology, Laboratory for Immunology, University Medical Centre
(3)
3 Unit of Special Laboratory Diagnostics, University Children's Hospital, University Medical Centre

Copyright

© Toplak et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.

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