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Table 4 Sample sizes requirements for genetic association studies

From: A comprehensive review of the genetics of juvenile idiopathic arthritis

MAF

10%

20%

30%

40%

 

Cases

controls

Cases

controls

Cases

Controls

Cases

Controls

OR

        

2.0

223

446

137

274

113

226

107

214

1.5

703

1406

415

830

332

664

304

608

1.3

1751

3502

1016

2032

798

1596

719

1438

  1. Table shows number of cases and controls that need to be typed to detect associations at a significance value of 0.05, power of 80%, for various minor allele frequencies, and odds ratios. A case: control ratio of 1:2 is assumed. OR: odds ratio; MAF: minor allele frequency.
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Pediatric Rheumatology

ISSN: 1546-0096