Figure 3
From: Mutations in CECR1 associated with a neutrophil signature in peripheral blood
Genome-wide gene expression. Heatmap showing genome-wide expression array in patients with mutations in CECR1 and RNA-seq analysis in patients with mutations in SAMHD1. Genes shown had a fold change greater than 5 (mean patients versus mean controls in the microarrays). Normalised expression levels for the microarray were expressed as fold change versus control samples in log scale. Similarly, for RNA-seq, normalised counts were expressed as fold change versus control samples in log scale. To generate the heatmap these log ratios (and control values of zero) were normalised between genes by setting the standard deviation of each gene to 1. Blue low expression, grey no change, red high expression. Samples shown: C = control; 1 = F785 patient 1 (ADA2); 2 = F750 patient 2 (ADA2); 3 = F104 (SAMHD1); 4 = F116 (SAMHD1).