Evaluation of anti-citrullinated type II collagen and anti-citrullinated vimentin antibodies in patients with juvenile idiopathic arthritis

Table 2 Anti-citrullinated type II collagen and vimentin antibody concentration and positivity in JIA subtypes (n=95)

	Poly RF+	Poly RF-	Oligo	Systemic	Enthesitis	Psoriatic
	n=16	n=36	n=24	n=13	n=3	n=3
	Mean±SD	Mean±SD	Mean±SD	Mean±SD	Mean±SD	Mean±SD
Citrullinated Type II Collagen (OD)	1.7±0.77	2.0±1.0	2.4±0.76	1.9±1.0	3.0±0.32	1.5±1.7
Positivity n(%)	2 (12.5%)	9 (25%)	7 (29.2%)	2 (15.4%)	2 (66.7%)	1 (33.3%)
Native Type II Collagen (OD)	1.4±0.82	1.8±1.1	2.4±0.97	1.5±0.78	2.4±0.60	1.4±1.7
Postivity n(%)	2 (12.5%)	7 (19.4%)	7 (29.2%)	0 (0%)	0 (0%)	1 (33.3%)
Citrullinated Vimentin 1–16 (OD)	0.63±0.79	0.47±0.17	0.45±0.30	0.49±0.25	0.38±0.12	0.34±0.08
Positivity n(%)	1 (6.25%)	3 (8.3%)	3 (12.5%)	3 (23.1%)	0 (0%)	0 (0%)
Native Vimentin 1–16 (OD)	0.67±0.80	0.50±0.17	0.47±0.29	0.55±0.26	0.42±0.12	0.35±0.07
Positivity n(%)	1 (6.25%)	0 (0%)	1 (4.2%)	0 (0%)	0 (0%)	0 (0%)
Citrullinated Vimentin 59–74 (OD)	0.74±0.80	0.55±0.22	0.51±0.24	0.46±0.2	0.45±0.12	0.36±0.1
Positivity n(%)	2 (12.5%)	2 (5.6%)	2 (8.3%)	1 (7.7%)	0 (0%)	0 (0%)
Native Vimentin 59–74 (OD)	0.69±0.82	0.44±0.20	0.38±0.22	0.42±0.18	0.26±0.11	0.29±0.05
Positivity n(%)	1 (6.25%)	1 (2.8%)	1 (4.2%)	0 (0%)	0 (0%)	0 (0%)

Continuous variables are expressed as means ± SD. N: Number of patients; OD: Optical density; RF: Rheumatoid factor. Cut points for positive values: Anti-citrullinated type II collagen antibodies (OD≥3.03), Native type II collagen antibodies (OD≥3.3), anti-citrullinated vimentin 1–16 antibodies (OD≥0.79), native vimentin 1–16 antibodies (OD≥1.3), anti-citrullinated vimentin 59–74 antibodies (OD≥0.81), native vimentin 59–74 antibodies (OD≥0.83).

ISSN: 1546-0096