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  1. Farber Disease is an autosomal-recessively inherited, lysosomal storage disorder caused by acid ceramidase deficiency and associated with distinct clinical phenotypes. Children with significant neurological in...

    Authors: Karoline Ehlert, Michael Frosch, Natalja Fehse, Axel Zander, Johannes Roth and Josef Vormoor
    Citation: Pediatric Rheumatology 2007 5:15
  2. Juvenile idiopathic arthritis (JIA) has long been assumed to be an autoimmune disease, triggered by aberrant recognition of "self" antigens by T-cells. However, systems biology approaches to this family of dis...

    Authors: James N Jarvis, Kaiyu Jiang, Howard R Petty and Michael Centola
    Citation: Pediatric Rheumatology 2007 5:13
  3. Cryopyrin-associated diseases may be characterized by rashes, fever, and sensorineural deafness, while celiac disease may present with symptoms of malabsorption and fatigue. Arthritis is seen in both condition...

    Authors: Marcus Shaker, Susan Edwards, Henry Chionuma, Eric Shamansky and Hal M Hoffman
    Citation: Pediatric Rheumatology 2007 5:12
  4. Juvenile systemic sclerosis (JSS) is a multisystem connective tissue disease characterized by skin fibrosis and internal organ involvement. It has a low prevalence, even in a tertiary facility setting. The pur...

    Authors: Ricardo AG Russo and María M Katsicas
    Citation: Pediatric Rheumatology 2007 5:6
  5. We review the clinical manifestations of "growing pains", the most common form of episodic childhood musculoskeletal pain. Physicians should be careful to adhere to clear clinical criteria as described in this...

    Authors: Yosef Uziel and Philip J Hashkes
    Citation: Pediatric Rheumatology 2007 5:5
  6. Loss of joint cartilage is a feature of destructive disease in JIA. The cartilage of most joints can be visualized with ultrasonography (US). Our present study focuses on discriminant validity of US in childre...

    Authors: Anne Helene Spannow, Elisabeth Stenboeg, Mogens Pfeiffer-Jensen and Troels Herlin
    Citation: Pediatric Rheumatology 2007 5:3
  7. An increased concentration of plasma homocysteine (Hcy) has toxic effects on vascular endothelium. This seems to be a risk factor of cardiovascular disease, premature stroke and venous thrombosis. The risk is ...

    Authors: Marcela Gonçalves, Vânia D'Almeida, Elvira M Guerra-Shinohara, Luciano C Galdieri, Claudio A Len and Maria Odete E Hilário
    Citation: Pediatric Rheumatology 2007 5:2

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