Paediatric autoimmune diseases with ELANE mutations associated with neutropenia

Table 1 Clinical manifestation of 3 patient

	Age	Gender	Duration of disease	Fever	oral ulcer	Lymphadenitis	Rash	Etiology	Infection site	ANC periodicity	Combined with antoimmune disease	Renal disorder	Hematological disorder
Patient 1	15 years old	male	6 months	+	-	+	+	Tuberculosis、EBV	Septicopyemia, gastrointestinal infection	3 weeks	SLE	+	+
Patient 2	1 year and 10 months old	female	More than 1 years	+	-	-	-	Staphylococcus aureus	Pneumonia, Otitis media	none	AIH	-	+
Patient 3	1 year and 10 months old	male	1 months	+	-	-	-	Preziosi water bacteria, Bacteroides forsythus, Streptococcus anginosus、Streptococcus mitis, Klebsiella pneumoniae, Micromonas micros, EBV	Omphalitis、Pneumonia	13 to 17days	ANCA-associated small vasculitis	-	+

ISSN: 1546-0096