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Table 4 Association of higher peak NT-proBNP levels with MIS-C clinical features reflecting severe disease and correlation with other MIS-C laboratory indices

From: Distinct phenotypes of multisystem inflammatory syndrome in children: a cohort study

 

Peak NT-proBNP levels, ng/l

Median (IQR)

P

Shock/hypotension Yes

No

7010 (2922–18,844)

582 (327–1095)

0.001

(U = 14.0)

Liver enzyme abnormalities Yes

No

8512 (2889–24,391)

3271 (867–8939)

0.05

(U = 124.0)

Hyponatremia < 133 mmol/l Yes

No

8031 (3570–20,578)

2107 (550–4810)

0.02

(U = 101.0)

Thrombocytopenia < 150 × 10E9/l Yes

No

8512 (3252–27,719)

3020 (680–9739)

0.01

(U = 106.0)

Ventricular dysfunction on echocardiogram Yes

No

23,840 (12,983–30,320)

3118 (1095–6981)

< 0·001

(U = 20.0)

Chest X-ray abnormalities Yes

No

12,217 (4957–28,182)

3115 (875-11185)

0.02

(U = 72.0)

Non-invasive/mechanical ventilation Yes

No

29,299 (13,093–38,446)

4290 (1228–12,792)

0.006

(U = 15.0)

 

Spearman’s Rho

P

Peak C-reactive protein, mg/l

0.39

0.01

Peak ferritin, µg/l

0.48

0.002

Peak D-dimer, mg/l

0.40

0.02

Peak troponin, ng/l

0.53

0.001

Sodium nadir, mmol/l

-0.43

0.006

Albumin nadir, g/l

-0.62

< 0.001

Platelet counts nadir, x10E9/l

-0.36

0.02

  1. Mann-Whitney U values are indicated between brackets. Variables not listed in the table lacked statistical significance. (NT-proBNP = N-terminal B-type natriuretic peptide, IQR = interquartile range)