Table 3 Distinct features of MIS-C patients warranting PICU admission or treatment with biologic agents
From: Distinct phenotypes of multisystem inflammatory syndrome in children: a cohort study
PICU admission | Treatment with biologicals | |||||
|---|---|---|---|---|---|---|
No (n = 27) | Yes (n = 30) | P | No (n = 49) | Yes (n = 8) | P | |
Shock/hypotension (n, %) | 20 (74) | 30 (100) | 0.003 | 42 (86) | 8 (100) | 0.58 |
Laboratory SARS-CoV-2 linkage (n, %) | 18 (67) | 29 (97) | 0.003 | 41 (84) | 6 (75) | 0.62 |
Peak CRP, mg/l (median, IQR) | 129.0 (57.6-234.3) | 192.0 (146.6-255.9) | 0.02 | 155.8 (101.0-200.7) | 240.9 (132.9-319.4) | 0.02 |
Peak ferritin, µg/l (median, IQR) | 376 (281–434) | 1356 (616–1795) | 0.001 | 473 (280–926) | 1380 (509–1753) | 0.05 |
Peak D-dimer, mg/l (median, IQR) | 2.40 (1.28–2.60) | 4.81 (3.56–5.28) | 0.006 | 2.44 (1.57–4.72) | 4.95 (1.52–5.48) | 0.32 |
Peak NT-proBNP, ng/l (median, IQR) | 2791 (582–7010) | 13,855 (8753–26,602) | < 0.001 | 4289 (1228–12,384) | 19,131 (4199–29,782) | 0.06 |
Peak troponin, ng/l (median, IQR) | 17 (10–38) | 42 (30–72) | 0.002 | 30 (14–66) | 67 (40–291) | 0.07 |
Albumin nadir, g/l (median, IQR) | 23 (20–25) | 19 (16–20) | 0.03 | 21 (18–26) | 19 (17–22) | 0.08 |
Ventricular dysfunction (n, %) | 2 (7) | 18 (60) | < 0.001 | 16 (33) | 4 (50) | 0.43 |
Chest X-ray abnormalities (n, %) | 3 (11) | 18 (60) | 0.002 | 16 (33) | 5 (63) | 0.44 |