The effect of etanercept therapy on adrenal steroid metabolism in juvenile idiopathic arthritis: a steroid metabolomics approach

Table 3 Urine metabolites ratios that reflect enzyme activities

Enzyme	Ratio	p value
CYP21A2–21-hydroxylase	THE + THF + aTHF)/PT	0.06
CYP17A1 – (17α-hydroxylase/17,20-lyase)	(THE + THF + aTHF)/(THA + TH B + aTHB)	0.39
CYP17A1 – (17α-hydroxylase/17,20-lyase)	(An + Et)/(THA + THB + aTHB)	0.57
CYP11B1 11β-hydroxylase	(THE + THF + aTHF)/100*THS:	0.32
11 β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2)	THE/ (THE + a THF )	0.53
11 β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2)	(a-Cl)+(b-Cl))/(a-C + b-C)	0.38
11 β-Hydroxysteroid dehydrogenase type 1 (11β -HSD1)	(THF + aTHF)/THE:	0.95
11 β-Hydroxysteroid dehydrogenase type 1 (11β -HSD1)	(a-Cl + b-Cl) /(a-Cl + b-Cl):	0.07
5α-reductase/5β reductase	An/Et	0.28
	11-OH-An/11-OH-Et	0.65
	aTHB/THB	0.78
	aTHF/THF	0.89

Significant values (p < 0.05), the p-values were calculated by comparing the metabolite ratios that reflect enzyme activities before etanercept treatment and 3 days following it

ISSN: 1546-0096