Table 1 Clinical characteristics of patients with Dry Synovitis
From: Dry synovitis, a rare entity distinct from juvenile idiopathic arthritis
Sex | Age at onset (years) | Age at diagnosis (years) | Year of diagnosis | No. joints involved at diagnosis | CRP (mg/l) | ESR (mm/h) | Treatment | Clinical and Imaging findings | ||
|---|---|---|---|---|---|---|---|---|---|---|
Imaging at diagnosis | Clinical course | Follow-up imaging | ||||||||
F | 8 | 9 | 2007 | 18 | 0,0 | 12 | NSAIDs, CS, MTX, anti-TNF | No synovial thickening, synovial enhancement, joint effusion or joint space narrowing | Good clinical response on anti-TNF treatment, although need for bilateral hip replacement | Progressive destruction of hip joints with joint effusion, joint space narrowing, bone edema and bone erosions |
F | 3 | 14 | 2009 | 30 | 0,0 | 8 | NSAIDs, CS, MTX, anti-TNF | Diffuse and moderate synovitis on wrists. Bone edema and geodes with discrete joint effusion on hips. Joint space narrowing and erosions on wrists and hips | Persistent, manifest limitation in mobility in multiple joints and need of bilateral hip replacement | Progressive destruction of hip joints with very moderate persistent joint effusion |
F | 4 | 10,4 | 2012 | 31 | 0,6 | 8 | NSAIDs, CS, MTX | Discrete hips joint effusion and osteochondral involvement with joint space narrowing and erosions | Persistent reduced mobility in the hip | Progressive destruction of hip joints. Development of diffuse and moderate articular and peritendinous synovitis on wrists |
F | 8 | 9,1 | 2014 | 71 | 5,3 | 2 | NSAIDs, CS, MTX | Diffuse and moderate articular and peritendinous synovitis with no joint effusion | Persistent limitation in mobility of wrists, ankles and elbow | No follow-up imaging available after start of treatment |
M | 1,2 | 4,9 | 2013 | 71 | 1,4 | 12 | NSAIDs, CS, MTX | Diffuse and moderate articular and peritendinous synovitis with no joint effusion or osteochondral damage | Clinically good response on treatment with persistence of only mild extension deficit in 1 wrist, some PIP joints and the neck | Persistent diffuse and moderate articular and peritendinous synovitis with no destructive damage on cartilage and bone |
M | 16 | 18,6 | 2014 | 26 | 3,5 | 7 | NSAIDs, CS, MTX, anti-TNF | Diffuse and moderate peritendinous synovitis with osteochondral damage (bone edema and geodes) and no joint effusion. | Persistent reduced mobility in wrists, MCP joints, hip and ankles | No follow-up imaging available after start of treatment |
F | 7 | 8 | 2016 | 71 | 12,0 | 15 | NSAIDs, CS, MTX, anti-TNF | Diffuse and moderate to intense articular and peritendinous synovitis with very limited bone edema and no joint effusion | Slowly improvement with persistence of mild limitation in mobility of both wrists, PIP 3&4 and MCP 1 & 2 of both hands | No follow-up imaging available after start of treatment |
F | 8 | 9,7 | 2017 | 71 | 4,1 | 12 | NSAIDs, CS, MTX | Diffuse and moderate to intense articular and peritendinous synovitis with very limited bone edema and no joint effusion | Persistent limitation in the left wrist and ankle | No follow-up imaging available after start of treatment |
F | 2,4 | 2,9 | 2012 | 8 | 1,6 | 67 | NSAIDs, CS, MTX | Diffuse and moderate articular synovitis | Clinical remission off treatment. Residual joint contractures at multiple joints and osteoporosis | No follow-up imaging available after start of treatment |
F | 5,9 | 6 | 2011 | 22 | 0,2 | 6 | NSAIDs, CS, MTX | Diffuse and moderate articular and peritendinous synovitis with limited osteochondral damage (bone edema and geodes) and no joint effusion | Persistent reduced mobility of wrists, MCP and PIP joints | Absence of inflammatory signs on MRI |
M | 3,1 | 5,8 | 2011 | 22 | 0,3 | 8 | NSAIDs, CS, MTX, anti-TNF | Diffuse and moderate articular and peritendinous synovitis with limited bone edema and no joint effusion | Reduced range of motion at wrists, MCP and PIP joints | Osteopenia, joint space narrowing on X-ray |
M | 4,9 | 10,2 | 2012 | 37 | 0.3 | 2 | NSAIDs, CS, MTX | Diffuse and moderate articular and peritendinous synovitis | Reduced range of motion at both elbows and wrists | Joint space narrowing but no erosions on X-ray |