Fig. 5

HLA expression in JIA patients. (A) HLA-DQA2 gene expression in pseudo-cells is suppressed in both healthy controls (left) but elevated to variable degrees in the JIA cases, with no effect of TNF stimulus. (B) Schematic map of the 300 kb region of the HLA encompassing HLA-DQA2 and HLA-DRB5 showing locations of 4 other HLA genes not differentially expressed by disease Status. Drawn from UCSC browser annotation, vertical bars represent exons and arrowheads direction of transcription. (C) Sunburst plot of documented disease associations with SNP variation in the vicinity of HLA-DQA1, highlighting JIA, plotted with HLA-spread (http://hla-spread.igib.res.in) [42]. Rings indicate increasing levels of haplotype resolution and each ray is a disease sub-type within the broader category