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Table 1 Baseline patient characteristics, overall and stratified by consensus treatment plan choice

From: First-line options for systemic juvenile idiopathic arthritis treatment: an observational study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans

Characteristic

All Patients

Biologic CTP

IL-1i/IL-6i

Non-Biologic CTP

GC/Methotrexate

Number of Patients

73

63

10

Age in years (median (IQR))

6.8 (4.1, 11.0)

7.0 (4.0, 11.3)

6.2 (5.6, 7.8)

Male sex (%)

44 (60.3)

40 (63.5)

4 (40.0)

Patient-Reported Race/Ethnicitya

 White (%)

48 (65.8)

43 (68.3)

5 (50.0)

 Black (%)

7 (9.6)

5 (7.9)

2 (20.0)

 Hispanic (%)

14 (19.2)

11 (17.5)

3 (30.0)

 Asian (%)

6 (8.2)

6 (9.5)

0 (0.0)

Days since symptom onset

(mean (SD))

46.4 (63.5)

49.3 (67.6)

28.1 (18.3)

Days since diagnosis

(median (IQR))

2.0 (0.0, 8.0)

1.0 (0.0, 8.0)

5.5 (0.5, 7.0)

Physician global assessment

(mean (SD))

6.0 (2.2)

6.3 (2.1)

4.7 (2.8)

Patient global assessment

(mean (SD))

5.6 (3.3)

5.7 (3.3)

5.4 (3.6)

Number of active joints

(mean (SD))

6.6 (7.6)

7.0 (8.0)

4.1 (4.4)

sJIA manifestations prior to enrollment

 Fever (%)

73 (100.0)

63 (100.0)

10 (100.0)

 Arthritis (%)

73 (100.0)

63 (100.0)

10 (100.0)

 Rash (%)

70 (95.9)

60 (95.2)

10 (100.0)

 Lymphadenopathy (%)

24 (32.9)

22 (34.9)

2 (20.0)

 Hepatomegaly or Splenomegaly (%)

15 (20.5)

13 (20.6)

2 (20.0)

 Serositis (%)

7 (9.6)

6 (9.5)

1 (10.0)

Laboratory values at time of enrolment (median (IQR))

 ESR (mm/hr)

73 (57, 97)

71 (54, 97)

88 (76, 90)

 CRP (mg/L)

15.4 (7.5, 58.1)

16.4 (7.5, 58.1)

13.5 (7.3, 51.4)

 Ferritin (ng/mL)

829 (249, 2603)

884 (290, 2652)

363 (81, 779)

 Hemoglobin (g/dL)

10.2 (9.1, 11.4)

10.7 (9.1, 11.5)

9.4 (9.0, 10.2)

 White blood cell count (109/L)

12.2 (8.5, 19.1)

12.0 (8.4, 19.0)

14.5 (10.6, 22.7)

 Platelets (109/L)

458 (353, 571)

452 (353, 565)

509 (375, 735)

CHAQ (mean (SD))

1.3 (1.0)

1.4 (1.0)

1.2 (0.9)

cJADAS-10 (median (IQR))

17.0 (10.5, 21.5)

17.5 (12.0, 21.0)

14.0 (8.0, 23.0)

  1. aMore than 1 race or ethnicity per patient could be reported