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Table 1 aPulmonary function test results before and after treatment with immunosuppression

From: Pulmonary manifestations of childhood-onset primary Sjogren’s syndrome (SS) masquerading as reactive airways disease in a male patient and review of interstitial lung disease associated with SS

 

Before Treatment

After 9 months of Treatment

After 3 years of Treatment

FVC

3.8 L (94% ref)

4.9 L (117% ref)

5.6 L (118% ref)

FEV1

2.8 L (80% ref)

3.6 L (99% ref)

4.1 L (100% ref)

FEV1/FVC ratio

73%

73%

73%

FEF25–75

2.2 L/s (56% ref)

2.8 L/s (71% ref)

3.3 L/s (72% ref)

TLC

5.8 L (120% ref)

6.5 L (129% ref)

7.6 L (142% ref)

RV

1.9 L (193% ref)

1.6 L (154% ref)

1.9 L (176% ref)

RV/TLC ratio

33%

25%

26%

DLCO

26.2 mL/mmHg/min (81% ref)

28.8 mL/mmHg/min (88% ref)

33.5 mL/mmHg/min (87% ref)

Interpretation

Spirometry

Mild-moderate obstructive pattern

Mild obstructive pattern

Mild obstructive pattern

Lung volumes

TLC, RV and RV/TLC elevated

TLC and RV elevated

TLC and RV elevated

DLCO

Normal

Normal (improved from previous)

Normal (improved from previous)

  1. aAbbreviations: FVC forced vital capacity, FEV1 forced expiratory volume in 1 second, FEF25–75 forced expiratory flow at 25–75% of FVC, TLC total lung capacity, RV residual volume, DLCO diffusing capacity for carbon monoxide, L liters, s second, ref reference, mL/mmHg/min milliliters/millimeters of mercury/minute