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Table 1 Descriptive characteristics of the participants with genotyping data who attended the “Focus24 + ” clinic

From: Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study

Category

Outcome

Sample size

Mean (SD)a

Demography

Age, months

2815

293.96 (9.46)

Sex, female

2815

1720 (61.1)a

Control variables

Autoimmune disease, ever versus never

1964

117 (6.0)a

Pigeon infestation, ever versus never

2540

282 (11.1)a

Mice infestation, ever versus never

2540

396 (15.6)a

Bee/wasp sting, ever versus never

2435

757 (31.1)a

Blood pressure

Systolic BP, mmHg

2799

116.03 (11.40)

Diastolic BP, mmHg

2798

66.73 (7.85)

Hypertension, > 140/90 mmHg

2798

7 (0.3)a

Isolated diastolic hyerptension, < 140/ > 90 mmHg

2791

7 (0.3)a

High normal blood pressure, > 120/80 mmHg

2798

138 (4.9)a

Anthropometry

Waist circumference, cm

2776

81.34 (12.39)

BMI, kg/m2

2782

24.83 (4.85)

BMI category

2782

 

Underweight, < 18.5 kg/m2

 

78 (2.8)a

Normal, 18.5–24.9 kg/m2

 

1643 (59.1)a

Overweight or obese, 25–39.9 kg/m2

 

1061 (38.1)a

Obese, 25–29.9 kg/m2

 

353 (12.7)a

FMI, kg/m2

2697

7.97 (3.73)

Blood biomarkers

hsCRP, mg/L

2056

1.36 (1.50)b

Glycoprotein acetylation, mmol/L

2338

1.23 (0.17)

Triglycerides, mmol/L

2309

0.94 (0.41)

HDL, mmol/L

2339

1.56 (0.42)

LDL, mmol/L

2337

2.44 (0.75)

Total cholesterol, mmol/L

2338

4.44 (0.83)

Apo-AI, g/L

2336

1.46 (0.21)

Apo-B, g/L

2336

0.68 (0.15)

Apo-B:AI

2336

0.47 (0.11)

Glucose, mmol/L

2321

3.90 (0.32)

Insulin, mU/L

2264

8.33 (4.53)

HOMA2_IR

2245

0.87 (0.47)

Early atherosclerosis/arteriosclerosis

cIMT, mm

1566

0.46 (0.05)

Pulse wave velocity, m/sec

1699

6.22 (0.94)

Cardiac structure and function

Ejection fraction, %

1433

63.75 (6.82)

Fractional shortening, %

1432

34.85 (5.08)

Mitral E/A

1597

1.97 (0.53)

E/e'

1519

5.99 (1.07)

Left atrial diameter, cm

1519

3.13 (0.42)

LVMI, g/m2.7

1461

30.53 (6.52)

  1. Apo-AI Apolioprotein-AI, Apo-B Apolipoprotein-B, BMI Body mass index, BP Blood pressure, cIMT carotid intima-media thickness, hsCRP high sensitivity C-reactive protein, FMI Fat mass index, HOMA2_IR Homeostasis Model Assessment 2 insulin reistance index, HDL High density lipoprotein cholesterol, LDL Low density lipoprotein cholesterol, LVMI Left ventricular mass index
  2. a For measures which are not continuous N (%) is reported.
  3. b For log hsCRP the geometric mean (SD) is 0.805 (2.81).