Fig. 2

Renal histology photomicrographs for patient 1 (A) and patient 2 (B). Light microscopy: Paraffin tissue sections from formalin-fixed kidney biopsy specimens were stained with Jones’ silver. Panel A from patient 1 shows a representative glomerulus with segmental fibrinoid necrosis and early cellular crescent formation (extracapillary hypercellularity is most pronounced at urinary pole near proximal tubule/PT). Panel B from patient 2 shows segmental fibrinoid necrosis in a single glomerulus, which was not accompanied by a crescent. In both panels the arrows point to ruptured glomerular capillary loop basement membranes. Fibrin tactoids are marked with asterisks. Original magnification 40x