Glucose metabolism in systemic juvenile idiopathic arthritis

Table 2 Comparison of characteristics and insulin sensitivity indices between OW/OB controls and OW/OB patients with systemic juvenile idiopathic arthritis (SJIA)

Variables	Control (n = 33)	OW/OB SJIA (n = 11)	p-value
Age (years), mean (SD)	13 (3.4)	12 (3.1)	0.492
Gender, M (%)	19 (58)	7 (64)	1.000
Puberty, N (%)			0.701
Prepuberty (Tanner I)	9 (27)	2 (18)
Puberty (Tanner II-V)	24 (73)	9 (82)
BMI (kg/m²), mean (SD)	28.4 (4.5)	27.6 (5.1)	0.664
BMI SDS, median (IQR)	2.4 (2.0–2.7)	2.3 (1.9–3.3)	0.978
FPG (mg/dL), mean (SD)	85 (6.8)	81 (8.8)	0.296
FPI (µIU/mL), median (IQR)	7.5 (3.9–10.3)	13 (11–15)	0.001
HOMA-IR, median (IQR)	1.5 (0.8–2.0)	2.6 (2.1–3.3)	0.001
WBISI, median (IQR)	5.4 (4.5–8.7)	3.7 (2.7–5.9)	0.024
IGI, median (IQR)	1.0 (0.8–1.9)	2.5 (2.0–3.5)	0.001
AUC-I / AUC-G, median (IQR)	0.4 (0.3–0.6)	0.7 (0.5–1.0)	0.019
DI, median (IQR)	7.5 (4.8–11.1)	8.6 (5.3–20.4)	0.247

AUC-G area under the curve of glucose (mg⋅min/dL), AUC-I area under the curve of insulin (µIU⋅min/mL), AUC-I / AUC-G (µIU⋅dL/mg⋅mL), BMI body mass index, DI disposition index (dL²/mg⋅mL), FPG fasting plasma glucose, FPI fasting plasma insulin, HOMA-IR homeostasis model assessment for insulin resistance (µIU⋅mg/mg⋅dL), IGI insulinogenic index (µIU⋅dL/mg⋅mL), IQR interquartile range, M male, OW/OB overweight/obesity, SD standard deviation, WBISI whole-body insulin sensitivity index (mL⋅dL/µIU⋅mg)

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