Table 1 Comparison of demographic and clinical characteristics between childhood leukemia patients with and without musculoskeletal involvement
From: Musculoskeletal involvement in childhood leukemia: Characteristics and survival outcomes
Factor | Total (N=1042) | No MSK involvement (N=961) | MSK involvement (N=81) | P value |
|---|---|---|---|---|
Median age, years (IQR) | 4.9 (2.9-9.0) | 4.9 (2.8-9.0) | 5.9 (3.5-9.3) | 0.052 |
Sex | 0.787 | |||
Male | 613 (58.8) | 567 (59.0) | 46 (56.8) | |
Female | 429 (41.2) | 394 (41.0) | 35 (43.2) | |
Year of diagnosis | 0.036 | |||
1979-1999 | 378 (36.3) | 354 (36.8) | 24 (29.6) | |
2000-2009 | 413 (39.6) | 385 (40.1) | 28 (34.6) | |
2010-2019 | 251 (24.1) | 222 (23.1) | 29 (35.8) | |
Morphology | <0.001 | |||
ALL | 726 (69.7) | 654 (68.1) | 72 (88.9) | |
AML | 316 (30.3) | 307 (31.9) | 9 (11.1) | |
ALL subtype | 0.028 | |||
B-cell | 401 (55.2) | 351 (53.7) | 50 (69.4) | |
T-cell | 71 (9.8) | 68 (10.4) | 3 (4.2) | |
FAB classification | 254 (35.0) | 235 (35.9) | 19 (26.4) | |
Fever | 0.005 | |||
Yes | 770 (73.9) | 699 (72.7) | 71 (87.7) | |
No | 272 (26.1) | 262 (27.3) | 10 (12.3) | |
Skin bleeding | <0.001 | |||
Yes | 444 (42.6) | 425 (44.2) | 19 (23.5) | |
No | 598 (57.4) | 536 (55.8) | 62 (76.5) | |
Hepatomegaly | 0.149 | |||
Yes | 909 (87.2) | 843 (87.7) | 66 (81.5) | |
No | 133 (12.8) | 118 (12.3) | 15 (18.5) | |
Splenomegaly | 0.043 | |||
Yes | 643 (61.7) | 602 (62.6) | 41 (50.6) | |
No | 399 (38.3) | 359 (37.4) | 40 (49.4) | |
Lymphadenopathy | 0.359 | |||
Yes | 808 (77.5) | 749 (77.9) | 59 (72.8) | |
No | 234 (22.5) | 212 (22.1) | 22 (27.2) | |
NCI risk group* | 0.017 | |||
Standard | 595 (57.4) | 538 (56.0) | 57 (70.4) | |
High | 447 (42.9) | 423 (44.0) | 24 (29.6) | |
Hb, g/dL | 7.0 (5.4-8.8) | 7.0 (5.3-8.7) | 8.0 (6.5-9.2) | 0.001 |
WBC, ×109/L | 17.1 (5.9-62.4) | 18.1 (6.1-69.2) | 9.0 (5.3-22.7) | <0.001 |
WBC, ×109/L | 0.002 | |||
<20 | 557 (53.5) | 500 (52) | 57 (70.4) | |
≥20 | 485 (46.5) | 461 (48) | 24 (29.6) | |
Platelets, ×109/L | 38.0 (18.0-80.0) | 36.0 (17.0-73.0) | 78.0 (43.0-168.0) | <0.001 |
Platelets, ×109/L | <0.001 | |||
<100 | 853 (81.9) | 804 (83.7) | 49 (60.5) | |
≥100 | 189 (18.1) | 157 (16.3) | 32 (39.5) | |
Blasts in peripheral blood, % | 50.0 (13.0-83.0) | 52.0 (14.8-85.0) | 26.0 (5.0-64.0) | <0.001 |
Blasts in peripheral blood | 0.044 | |||
Absence | 106 (10.2) | 92 (9.6) | 14 (17.3) | |
Presence | 935 (89.8) | 868 (90.4) | 67 (82.7) | |
Calcium, mg% | 9.4 (8.9-9.8) | 9.4 (8.9-9.8) | 9.5 (9.0-10.0) | 0.104 |
Phosphate, mg% | 4.7 (3.9-5.4) | 4.7 (3.9-5.4) | 4.7 (4.2-5.3) | 0.996 |
Uric acid, mg% | 5.2 (3.9-6.8) | 5.2 (4.0-6.9) | 5.0 (3.7-6.3) | 0.168 |
ALP, U/L | 141.0 (105.0-193.0) | 141.0 (106.0-193.0) | 135.0(99.8-190.8) | 0.725 |
LDH, U/L | 1047.0(628.0-2171.5) | 1065.0(652.0-2207.5) | 831.0(532.8-1465.2) | 0.013 |
LDH, U/L | 0.008 | |||
<500 | 116 (12.9) | 99 (12) | 17 (23.6) | |
≥500 | 782 (87.1) | 727 (88) | 55 (76.4) |