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Table 3 Comparison of clinical features between JIA patients with and without CD

From: In a large Juvenile Idiopathic Arthritis (JIA) cohort, concomitant celiac disease is associated with family history of autoimmunity and a more severe JIA course: a retrospective study

 

JIA patients without CD

N = 321

JIA patients with CD

N = 8

P-value§

Sex (female), n (%)

240 (74.8)

6 (75)

0.45

Age at JIA diagnosis, yrs, median (IQR)

4 (2.2–7.9)

4.4 (3.6–6.1)

0.32‡

JIA Subtype, n (%)

 Oligoarticular

213 (66.4)

2 (25)

0.02*

 Polyarticular

55 (17.1)

2 (25)

0.63

 Systemic

28 (8.7)

1 (12.5)

0.53

 Undifferentiated

12 (3.7)

3 (37.5)

0.004*

Follow-up duration, yrs, median (IQR)

5 (2.7–8.8)

9.4 (3.6–12.4)

0.13‡

Uveitis, n (%)

46 (14.3)

2 (25)

0.33

Family history of autoimmunity, n (%)

147 (45.8)

7 (87.5)

0.03*

ANA positivity, n (%)

125 (38.9)

3 (37.5)

1

DMARD therapy, n (%)

 cDMARDs

233 (72.6)

7 (87.5)

0.7

 bDMARDs

127 (39.6)

7 (87.5)

0.009*

 cDMARDs + bDMARDs

117 (36.4)

7 (87.5)

0.005*

  1. JIA Juvenile Idiopathic Arthritis, CD Celiac Disease, IQR Interquartile Range, yrs years, ANA Antinuclear Antibody, DMARD Disease-modifying Anti-rheumatic Drug, cDMARDs conventional Disease-modifying Anti-rheumatic Drugs, bDMARDs biological Disease-modifying Anti-rheumatic Drugs
  2. § By Fisher’s exact test unless otherwise specified. ‡ By Mann–Whitney U test. *Statistically significant