Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 | |
---|---|---|---|---|---|---|---|---|
Sex | F | F | M | M | F | F | F | F |
Current age (years) | 16.5 | 16.6 | 13.8 | 8.4 | 14.1 | 21.6 | 13.5 | 12.1 |
JIA subtype | Polyarticular | Undifferentiated | Systemic | Oligoarticular | Oligoarticular | Undifferentiated | Polyarticular | Undifferentiated |
Age of JIA onset (years) | 4.3 | 4.1 | 5 | 6.5 | 4.5 | 3.4 | 13 | 3 |
ANA ( ±) | - | + | + | - | + | - | - | - |
Follow-up duration (years) | 12.2 | 12.5 | 8.8 | 1.9 | 9.6 | 15.2 | 0.5 | 9.1 |
Age at CD diagnosis (years) | 5 | 14.6 | 10.9 | 6.10 | 5.2 | 3.6 | 9.7 | 3.9 |
Anti-tTG (fold increase over ULN) | 125 | 10 | 2.3 | 11 | 7.5 | 1.8 | 7.6 | 3 |
EMA ( ±) | + | + | - | + | + | + | + | + |
Small intestinal biopsy | + | n.d. | + | + | + | + | n.d. | + |
Marsh classification | T3b\c | n.d. | T3c | T3c | T3c | T3b | n.d. | T0 |
HLA-DQ2\-DQ8 | n.d. | DQ2.5 | DQ2 and DQ8 | n.d. | n.d. | n.d. | n.d. | DQ2 |
Gastrointestinal symptoms | No | No | Yes | No | No | No | Yes | Yes |
Extra-intestinal symptoms of CD | No | No | Yes | No | No | No | Yes | No |
JIA therapy at CD diagnosis | NSAID | ADA | PDN INDO; CsA; TCZ | NSAID | MTX | MTX | NA | NAa |
Relapse upon GFD | Yes | Yes | No | Yes | Yes | Yes | NA | Yes |
Positive family history of autoimmune disease | No | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Family history of autoimmune disease specifics | NA | Psoriasis | Rheumatoid arthritis, type 1 diabetes | Thyroiditis | Thyroiditis, vitiligo | Psoriasis | Psoriasis, CD | Psoriasis |
Co-occurrence of other autoimmune disorders | No | Uveitis | No | No | No | No | No | Uveitis |